| 项目编号 |
PRJCA006827 |
| 项目标题 |
A case of Sarocladium strictum meningoencephalitis in an immunocompetent patient after invasive operation |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
|
| 物种名称 |
Sarocladium strictum
|
| 描述信息 |
As an opportunistic phytopathogen, Sarocladium strictum has only been shown to cause neurological disease in immunocompromised patients, where antifungal therapy was not effective. We report a case of Sarocladium strictum meningoencephalitis in an apparently immunocompetent young woman who presented with severe headache and slight fever after undergoing transnasal endoscopic repair of cerebrospinal fluid rhinorrhea. Chronic sinusitis and suspicious intracranial fungal lesions were observed on enhanced magnetic resonance imaging (MRI). Both culture and metagenomic next-generation sequencing of her cerebrospinal fluid were positive for Sarocladium strictum. After local debridement, treatment with amphotericin B plus voriconazole and Ommaya reservoir implantation, the patient improved significantly. Unfortunately, her symptoms worsened again despite plenty of antifungal therapy for a month. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2021-10-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 34859014
|
Case Report: A Case of Sarocladium strictum Meningoencephalitis in an Immunocompetent Patient After Invasive Operation
|
Frontiers in Medicine
|
10.3389/fmed.2021.762763
|
2021
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2019YFC0118600
|
|
| Xuanwu Hospital Teaching Reform Foundation
|
|
2020XWJXGG-09
|
|
| National Key Research and Development Program of China Research on the Precision Diagnosis, Treatment, and Integrated Prevention, Control for the Elderly with Common Infectious Disease
|
|
2020YFC2005403
|
|
|
|
| 提交者 |
Ye
Zhang (zhangye@hugobiotech.com)
|
| 提交单位 |
Hugobiotech Beijing Co.,Ltd. |
| 提交日期 |
2021-10-11 |
