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项目编号 PRJCA006991
项目标题 Gut microbiota-derived metabolic abnormalities of sphingosine contribute to testicular cell apoptosis in a prediabetic model
涉及领域 Medical
数据类型 16S
物种名称 Ovis aries
描述信息 We reveal that using the untargeted metabolome and 16s-rDNA sequencing, a dramatic difference in the metabolism of sphingosine induced by microbiota dysbiosis was shown in a prediabetic model. Moreover, we demonstrate that an obvious block in the developmental stage of round spermatids was found in this experimental model of prediabetes, along with an increased quantity of testicular apoptotic cells, owing to increased levels of sphingosine in the testes and circulating blood. Administration of melatonin alleviates the symptoms of prediabetes, especially those of impaired spermatogenesis, which results from the restoration of gut microbiota and metabolic levels of sphingosine.
样品范围 gut microbiota
发布日期 2021-12-17
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
35606800 Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep BMC Biology 10.1186/s12915-022-01326-y 2022
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China 31900595
National Natural Science Foundation of China 32000582
提交者 Yanting Hu (15762183856@163.com)
提交单位 Inner Mongolia University
提交日期 2021-10-26

项目包含数据信息

资源名称 描述
BioSample (27)  show -
GSA (1) -
CRA005272 Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep