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Accession PRJCA006991
Title Gut microbiota-derived metabolic abnormalities of sphingosine contribute to testicular cell apoptosis in a prediabetic model
Relevance Medical
Data types 16S
Organisms Ovis aries
Description We reveal that using the untargeted metabolome and 16s-rDNA sequencing, a dramatic difference in the metabolism of sphingosine induced by microbiota dysbiosis was shown in a prediabetic model. Moreover, we demonstrate that an obvious block in the developmental stage of round spermatids was found in this experimental model of prediabetes, along with an increased quantity of testicular apoptotic cells, owing to increased levels of sphingosine in the testes and circulating blood. Administration of melatonin alleviates the symptoms of prediabetes, especially those of impaired spermatogenesis, which results from the restoration of gut microbiota and metabolic levels of sphingosine.
Sample scope gut microbiota
Release date 2021-12-17
Publication
PubMed ID Article title Journal name DOI Year
35606800 Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep BMC Biology 10.1186/s12915-022-01326-y 2022
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China 31900595
National Natural Science Foundation of China 32000582
Submitter Yanting Hu (15762183856@163.com)
Organization Inner Mongolia University
Submission date 2021-10-26

Project Data

Resource name Description
BioSample (27)  show -
GSA (1) -
CRA005272 Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep