| Accession |
PRJCA007028 |
| Title |
Gut microbiota-derived metabolic abnormalities of sphingosine contribute to testicular cell apoptosis |
| Relevance |
Medical |
| Data types |
metabolome
|
| Organisms |
Ovis aries
|
| Description |
Administration of melatonin alleviates the symptoms of prediabetes, especially those of impaired spermatogenesis, which results from the restoration of gut microbiota and metabolic levels of sphingosine. Our results reveal that sphingosine contributed to the disruption of spermatogenesis and could be a disease marker; furthermore, melatonin represents a potential prebiotic agent for the treatment of male infertility caused by prediabetes and its complications. |
| Sample scope |
Ovisaries |
| Release date |
2021-10-29 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35606800
|
Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep
|
BMC Biology
|
10.1186/s12915-022-01326-y
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
31900595
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
32000582
|
|
|
|
| Submitter |
Peng
Sun (1318329288@qq.com)
|
| Organization |
Inner Mongolia University |
| Submission date |
2021-10-29 |
