| 项目编号 |
PRJCA007028 |
| 项目标题 |
Gut microbiota-derived metabolic abnormalities of sphingosine contribute to testicular cell apoptosis |
| 涉及领域 |
Medical |
| 数据类型 |
metabolome
|
| 物种名称 |
Ovis aries
|
| 描述信息 |
Administration of melatonin alleviates the symptoms of prediabetes, especially those of impaired spermatogenesis, which results from the restoration of gut microbiota and metabolic levels of sphingosine. Our results reveal that sphingosine contributed to the disruption of spermatogenesis and could be a disease marker; furthermore, melatonin represents a potential prebiotic agent for the treatment of male infertility caused by prediabetes and its complications. |
| 样品范围 |
Ovisaries |
| 发布日期 |
2021-10-29 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35606800
|
Elevated testicular apoptosis is associated with elevated sphingosine driven by gut microbiota in prediabetic sheep
|
BMC Biology
|
10.1186/s12915-022-01326-y
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
31900595
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
32000582
|
|
|
|
| 提交者 |
Peng
Sun (1318329288@qq.com)
|
| 提交单位 |
Inner Mongolia University |
| 提交日期 |
2021-10-29 |
