| Accession |
PRJCA007181 |
| Title |
Characterization of BDE-47-induced prepubertal testicular toxicity in mice via single-cell RNA-sequencing |
| Relevance |
Environmental |
| Data types |
Single cell sequencing
|
| Organisms |
Mus musculus
|
| Description |
Here, ScRNA-seq was employed to dissect BDE-47-induced prepubertal testicular toxicity in mice. Our results revealed comprehensive heterogeneous information of differential expressed genes, signaling pathways, transcriptional factors, and ligand-receptors in major testis cell types upon BDE-47-treatment in mouse testis. Our ScRNA-seq atlas provides novel insight into underlying mechanisms and pathways for BDE-47-associated testicular injury at a single-cell level. Our results can also serve as an important resource for future dissection of BDE-47-induced male reproduction toxicity. |
| Sample scope |
Environment |
| Release date |
2021-11-11 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35875604
|
Characterization of 2,2,4,4-tetrabromodiphenyl ether (BDE47)-induced testicular toxicity via single-cell RNA-sequencing
|
Precision Clinical Medicine
|
10.1093/pcmedi/pbac016
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Shenzhen Science and Technology Innovation Commission
|
|
JCYJ20210324114014039
|
|
|
|
| Submitter |
Siyu
Xia (syxbestmayer@whu.edu.cn)
|
| Organization |
Southern University of Science and Technology |
| Submission date |
2021-11-11 |
