| 项目编号 |
PRJCA007181 |
| 项目标题 |
Characterization of BDE-47-induced prepubertal testicular toxicity in mice via single-cell RNA-sequencing |
| 涉及领域 |
Environmental |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Here, ScRNA-seq was employed to dissect BDE-47-induced prepubertal testicular toxicity in mice. Our results revealed comprehensive heterogeneous information of differential expressed genes, signaling pathways, transcriptional factors, and ligand-receptors in major testis cell types upon BDE-47-treatment in mouse testis. Our ScRNA-seq atlas provides novel insight into underlying mechanisms and pathways for BDE-47-associated testicular injury at a single-cell level. Our results can also serve as an important resource for future dissection of BDE-47-induced male reproduction toxicity. |
| 样品范围 |
Environment |
| 发布日期 |
2021-11-11 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35875604
|
Characterization of 2,2,4,4-tetrabromodiphenyl ether (BDE47)-induced testicular toxicity via single-cell RNA-sequencing
|
Precision Clinical Medicine
|
10.1093/pcmedi/pbac016
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Shenzhen Science and Technology Innovation Commission
|
|
JCYJ20210324114014039
|
|
|
|
| 提交者 |
Siyu
Xia (syxbestmayer@whu.edu.cn)
|
| 提交单位 |
Southern University of Science and Technology |
| 提交日期 |
2021-11-11 |
