| Accession |
PRJCA007829 |
| Title |
Human peripheral blood leucocytes DNA methylation chip |
| Relevance |
Medical |
| Data types |
Epigenomics
|
| Organisms |
Homo sapiens
|
| Description |
DNA methylation is an important epigenetic regulatory mechanism and plays a critical role in regulating gene expression. Previous studies showed that DNA methylation inhibited transcription and that hypomethylation increased downstream gene expression levels. Site-specific DNA methylation is associated with many complex human diseases. Studies have shown that global genomic DNA methylation in peripheral blood correlates with the severity of hypertension. Therefore, screening the changes of DNA methylation may reveal the mechanisms of hypertension and provide theoretical guidance for prevention and treatment of hypertension. 132 individuals (hypertensive patients, pre-hypertensive patients, and healthy controls) who were enrolled and subjected to a genome-wide methylation analysis using the Illumina 450K BeadChip. |
| Sample scope |
Multiisolate |
| Release date |
2022-02-04 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Jiayun
Liu (bcx316@163.com)
|
| Organization |
Xijing Hospital, Fourth Military Medical University (Air Force Medical University) |
| Submission date |
2022-01-05 |
