项目编号 PRJCA007843
项目标题 Whole genome sequencing data of 1001 Tibetans
涉及领域 Evolution
先导项目

eGPS: evolutionary Genotype-Phenotype Systems biology

Plateau Adaptability

Analysis of adaptive traits in the Qinghai Tibet Plateau

数据类型 Whole genome sequencing
Raw sequence reads
物种名称 Homo sapiens
描述信息 In recent human evolution, the genetic adaptation of Tibetans to high-altitude environment is viewed as a classical case. we present whole genome sequencing data of 1001 Tibetans, covering the major populated areas of the Qinghai-Tibetan Plateau in China. We identified 35 million variants,Utilizing the large-scale WGS data, we constructed a comprehensive map of allele frequency and linkage disequilibrium, and provided a population-specific genome reference panel (referred as 1KTGP). Overall, the large-scale Tibetan WGS data and the identified adaptive variants/genes can serve as a valuable resource for future genetic and medical studies of high altitude populations.
样品范围 Multiisolate
发布日期 2023-03-28
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
37055782 Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans Genome Biology 10.1186/s13059-023-02912-1 2023
37643619 Polygenic adaptation leads to a higher reproductive fitness of native Tibetans at high altitude Current Biology 10.1016/j.cub.2023.08.021 2023
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Chinese Academy of Sciences (CAS) N/A
Chinese Academy of Sciences (CAS) Strategic Priority Research Program of Chinese Academy of Sciences (CAS) XDB13000000
提交者 Bing Su (sub@mail.kiz.ac.cn)
提交单位 Kunming Institute of Zoology, Chinese Academy of Sciences
提交日期 2022-01-05

项目包含数据信息

资源名称 描述
BioSample (1001)  show -