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项目编号 PRJCA007907
项目标题 Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport
涉及领域 Medical
数据类型 Metagenome
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
物种名称 mouse gut metagenome
Mus musculus
描述信息 Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by social communication deficits and stereotyped behaviors, is believed to be affected by the gut microbiota. However, how gut commensal bacteria modulate brain function in ASD remains unclear. Here, we used chromodomain helicase DNA-binding protein 8 (CHD8) haploinsufficient mice as a model of ASD to elucidate the pathways through which the host and gut microbiota interact with each other. We found that increased levels of amino acid transporters in the intestines of the mouse model of ASD contribute to the high level of serum glutamine and the increased excitation/inhibition (E/I) ratio in the brain. In addition, elevated α-defensin levels in the haploinsufficient mice resulted in dysregulation of the gut microbiota characterized by a reduced abundance of Bacteroides. Furthermore, supplementation with Bacteroides uniformis improved the ASD-like behaviors and restored the E/I ratio in the brain by decreasing intestinal amino acid transport and the serum glutamine levels. Together, our study reveals a new mechanism by which the gut microbiota regulates the host ASD-relevant phenotypes and provides a new potential treatment for ASD.
样品范围 Multiisolate
发布日期 2022-01-18
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
35241668 Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8 +/- mouse model of ASD-like behavior Nature Communications 10.1038/s41467-022-28746-2 2022
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Beijing Natural Science Foundation JQ18020
National Natural Science Foundation of China (NSFC) 32025009
National Natural Science Foundation of China (NSFC) 91951209
National Natural Science Foundation of China (NSFC) 31722031
National Key R&D Programmes of China (NKPs) 2018YFC0910400
提交者 bing zhang (bingzhang_bio@qq.com)
提交单位 Beijing Institutes of Life Science, Chinese Academy of Sciences
提交日期 2022-01-10

项目包含数据信息

资源名称 描述
BioSample (60)  show -
GSA (3) -
CRA005899 scRNA-seq data for Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport
CRA005819 Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport
CRA005826 Bulk RNA-seq Data for Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport