| Accession | PRJCA007907 | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Title | Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport | ||||||||||||||||||||||||
| Relevance | Medical | ||||||||||||||||||||||||
| Data types |
Metagenome
Transcriptome or Gene expression Raw sequence reads Single cell sequencing |
||||||||||||||||||||||||
| Organisms |
mouse gut metagenome
Mus musculus |
||||||||||||||||||||||||
| Description | Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by social communication deficits and stereotyped behaviors, is believed to be affected by the gut microbiota. However, how gut commensal bacteria modulate brain function in ASD remains unclear. Here, we used chromodomain helicase DNA-binding protein 8 (CHD8) haploinsufficient mice as a model of ASD to elucidate the pathways through which the host and gut microbiota interact with each other. We found that increased levels of amino acid transporters in the intestines of the mouse model of ASD contribute to the high level of serum glutamine and the increased excitation/inhibition (E/I) ratio in the brain. In addition, elevated α-defensin levels in the haploinsufficient mice resulted in dysregulation of the gut microbiota characterized by a reduced abundance of Bacteroides. Furthermore, supplementation with Bacteroides uniformis improved the ASD-like behaviors and restored the E/I ratio in the brain by decreasing intestinal amino acid transport and the serum glutamine levels. Together, our study reveals a new mechanism by which the gut microbiota regulates the host ASD-relevant phenotypes and provides a new potential treatment for ASD. | ||||||||||||||||||||||||
| Sample scope | Multiisolate | ||||||||||||||||||||||||
| Release date | 2022-01-18 | ||||||||||||||||||||||||
| Publication |
|
||||||||||||||||||||||||
| Grants |
|
||||||||||||||||||||||||
| Submitter | bing zhang (bingzhang_bio@qq.com) | ||||||||||||||||||||||||
| Organization | Beijing Institutes of Life Science, Chinese Academy of Sciences | ||||||||||||||||||||||||
| Submission date | 2022-01-10 |
| Resource name | Description |
|---|---|
| BioSample (60) show | - |
| GSA (3) | - |
| CRA005899 | scRNA-seq data for Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport |
| CRA005819 | Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport |
| CRA005826 | Bulk RNA-seq Data for Bacteroides uniformis restores ASD-like phenotypes by reducing intestinal amino acid transport |