| Accession | PRJCA008053 | ||||||||
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| Title | The genetic and epigenetic regulation of stem cell senescence | ||||||||
| Relevance | Model organism | ||||||||
| Data types |
Epigenomics
Transcriptome or Gene expression |
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| Organisms |
Mus musculus
Mus |
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| Description | The maintenance of hematopoietic stem/progenitor cell (or cardiac stem/progenitor cell) function is currently the limiting factor for biological aging and in vitro expansion of hematopoietic stem/progenitor cell (or cardiac stem/progenitor cell) for transplantation therapy. This project uses aged wild-type mouse models and multiple epigenetic factor knockout mouse models to study epigenetic modification markers in the aging process of hematopoietic stem/progenitor cells (or cardiac stem/progenitor cells), and their The relationship with aging and the function of regulatory mechanisms in the homeostasis maintenance and fate determination of hematopoietic stem/progenitor cells (or cardiac stem/progenitor cells); elucidation of important epigenetic regulators for hematopoietic stem/progenitor cells (or cardiac stem/progenitor cells) Regulation mechanism of self-renewal capacity in aging state; using compounds or gene therapy to manipulate related epigenetic modifications to interfere with the aging process of hematopoietic stem/progenitor cells (or cardiac stem/progenitor cells). The research of this topic will help to clarify the molecular basis of hematopoietic stem/progenitor cell (or cardiac stem/progenitor cell) aging, and provide first-hand experimental basis and theoretical guidance for intervention in aging and stem cell expansion and clinical application in vitro. | ||||||||
| Sample scope | Monoisolate | ||||||||
| Release date | 2022-12-31 | ||||||||
| Grants |
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| Submitter | zhenyu Ju (zhenyuju@163.com) | ||||||||
| Organization | Jinan University | ||||||||
| Submission date | 2022-01-21 |