| 项目编号 |
PRJCA008174 |
| 项目标题 |
High-dimensional single-cell analysis delineates ferroptosis mediated tissue injury in retinal ischemia/reperfusion |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Retinal ischemia/reperfusion (I/R) is a major cause of vision loss and impairment and a common underlying mechanism associated with eye diseases. The regenerative capacity of the diseased human retina is limited. During the reperfusion process, inflammation and tissue injury were triggered, which were mediated by immunocytes and cytokines. However, the mechanisms initiating I/R-induced inflammation and driving immunocytes activation remained largely unknown. Here, we discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in I/R-induced retinopathy. By using single-cell RNA sequencing and biochemistry investigations, we have firstly investigated the comprehensively characterize the transcriptional changes of I/R model in distant wild type mice. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-11-02 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36289494
|
Single-cell RNA sequencing reveals a landscape and targeted treatment of ferroptosis in retinal ischemia/reperfusion injury
|
Journal of Neuroinflammation
|
10.1186/s12974-022-02621-9
|
2022
|
| 40442071
|
Reln-Dab1 pathway mitigates retinal ganglion cell apoptosis in retinal ischemia-reperfusion injury
|
Cell Death & Disease
|
10.1038/s41419-025-07742-6
|
2025
|
| 39093964
|
Modulating amacrine cell–derived dopamine signaling promotes optic nerve regeneration and preserves visual function
|
Science Advances
|
10.1126/sciadv.ado0866
|
2024
|
|
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| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
|
|
|
|
|
| 提交者 |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| 提交单位 |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| 提交日期 |
2022-02-07 |
