| 项目编号 |
PRJCA008206 |
| 项目标题 |
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity |
| 涉及领域 |
Model organism |
| 数据类型 |
Whole genome sequencing
Epigenomics
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular subtypes of pancreatic cancer, predict numerous chromatin accessibility peaks associated with gene regulatory networks, discover regulatory noncoding mutations with potential as cancer drivers, and reveal the chromatin accessibility signatures associated with drug sensitivity. These results not only provide the chromatin accessibility atlas of pancreatic cancer but also suggest a systematic approach to comprehensively understand the gene regulatory network of pancreatic cancer in order to advance diagnosis and potential personalized medicine applications. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2022-02-16 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35449156
|
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
|
Nature Communications
|
10.1038/s41467-022-29857-6
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
Nos.32125013
|
|
| Chinese Academy of Sciences (CAS)
|
|
Nos.XDA16020905
|
|
| National key research and 1058 development program of China
|
|
Nos.2017YFA0505500
|
|
|
|
| 项目相关网站链接 |
| 项目相关网站链接 |
网站信息描述 |
| https://www.biosino.org/node |
All data can be viewed in NODE by pasting accession OEP001744 into the text search box or through the URL: https://www.biosino.org/node/project/detail/OEP001744 |
|
|
| 提交者 |
dong
gao (dong.gao@sibcb.ac.cn)
|
| 提交单位 |
Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences |
| 提交日期 |
2022-02-10 |
