| Accession | PRJCA008291 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Title | Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T cell infiltration in preclinical hepatocellular carcinoma models | ||||||||
| Relevance | Medical | ||||||||
| Data types |
Exome
Transcriptome or Gene expression Raw sequence reads Single cell sequencing |
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| Organisms | Mus musculus | ||||||||
| Description | Here, we aimed to evaluate the efficacy of PD-1 antibody combined with neoantigen peptide vaccines in the HCC treatment and further explore potential antitumor mechanisms. Neoantigen peptide vaccine for murine HCC cell line Hepa1-6 was developed. Then the synergistic efficacy and related molecular mechanisms were evaluated by orthotopic HCC mouse model, single cell RNA sequencing, tetramer flow cytometry and immunofluorescence, etc. | ||||||||
| Sample scope | Synthetic | ||||||||
| Release date | 2022-02-16 | ||||||||
| Grants |
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| Submitter | Xiaolong Liu (xiaoloong.liu@gmail.com) | ||||||||
| Organization | Mengchao Hepatobiliary Hospital of Fujian Medical University | ||||||||
| Submission date | 2022-02-16 |