Accession PRJCA008291
Title Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T cell infiltration in preclinical hepatocellular carcinoma models
Relevance Medical
Data types Exome
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
Organisms Mus musculus
Description Here, we aimed to evaluate the efficacy of PD-1 antibody combined with neoantigen peptide vaccines in the HCC treatment and further explore potential antitumor mechanisms. Neoantigen peptide vaccine for murine HCC cell line Hepa1-6 was developed. Then the synergistic efficacy and related molecular mechanisms were evaluated by orthotopic HCC mouse model, single cell RNA sequencing, tetramer flow cytometry and immunofluorescence, etc.
Sample scope Synthetic
Release date 2022-02-16
Grants
Agency program Grant ID Grant title
Fujian Provincial Science and Technology Department 2019Y3001
Submitter Xiaolong    Liu  (xiaoloong.liu@gmail.com)
Organization Mengchao Hepatobiliary Hospital of Fujian Medical University
Submission date 2022-02-16

Project Data

Resource name Description
BioSample (21)  show -
GSA (1) -
CRA006378 Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+ tissue-resident memory T cell infiltration in preclinical hepatocellular carcinoma models