| 项目编号 |
PRJCA008320 |
| 项目标题 |
A phenogenetic axis that modulates clinical manifestation and treatment outcome in myeloid neoplasms |
| 涉及领域 |
Medical |
| 数据类型 |
clinical data
|
| 物种名称 |
Homo
|
| 描述信息 |
Hematologic neoplasms are often underrepresented in pan-cancer genomic studies. Here we report an analysis of 730 myeloid neoplasm patients, along with 462 lymphoid neoplasm cases serving as the outgroup, that identified gene clusters with distinct mutational spectra cross eight diagnoses. Moreover, we found that genetic aberrations and clinical manifestations jointly defined a 'Pan-Myeloid Axis' along which cancer genes were aligned in a sequential order. Utilizing relational information of gene mutations along this axis improved predictive accuracy of treatment outcome in adult patients of de novo acute myeloid leukemia and myelodysplastic syndromes. |
| 样品范围 |
Not applicable |
| 发布日期 |
2022-02-17 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms
|
Cancer Research Communications
|
10.1158/2767-9764.CRC-21-0194
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| State Key Laboratory of Experimental Hematology
|
|
Z20-01
|
|
| Tianjin Science and Technology Plan
|
|
20ZYJDSY00010
|
|
|
|
| 提交者 |
Xueou
Liu (liuxueou@ihcams.ac.cn)
|
| 提交单位 |
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences |
| 提交日期 |
2022-02-17 |
