| Accession |
PRJCA008385 |
| Title |
Metagenomic Next-Generation Sequencing versus Traditional Pathogen Detection in the Diagnosis of Infection after Allogeneic Hematopoietic Stem Cell Transplantation in Children |
| Relevance |
Medical |
| Data types |
Metagenome
|
| Organisms |
human metagenome
|
| Description |
We compared metagenomic next-generation sequencing (mNGS) and traditional pathogen detection in investigating the pathogens of infections (such as bloodstream infections, pulmonary infections, and central nervous system (CNS) infections) in pediatric allo-HSCT recipients. This study retrospectively analyzed 101 pediatric recipients of allo-HSCT, including 54 bronchoalveolar lavage fluid samples, 32 blood samples, and 15 cerebrospinal fluid samples. Eighty-seven were diagnosed with post-transplant infectious diseases and 14 with non-infectious diseases eventually. The sensitivity and specificity of mNGS were compared to traditional pathogen detection methods. |
| Sample scope |
Multispecies |
| Release date |
2022-04-22 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 35509305
|
Metagenomic Next-Generation Sequencing vs. Traditional Pathogen Detection in the Diagnosis of Infection After Allogeneic Hematopoietic Stem Cell Transplantation in Children
|
Frontiers in Microbiology
|
10.3389/fmicb.2022.868160
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Clinical Applied Drug Research Fund of Guangdong Province
|
|
2020ZJ02
|
|
| Internal scientific research fund of the Institute of Pediatrics, Guangzhou Women and Children's Medical Center
|
|
YIP-2019-017
|
|
|
|
| Submitter |
Ye
Zhang (zhangye@hugobiotech.com)
|
| Organization |
Hugobiotech Beijing Co.,Ltd. |
| Submission date |
2022-02-22 |
