| 项目编号 |
PRJCA008385 |
| 项目标题 |
Metagenomic Next-Generation Sequencing versus Traditional Pathogen Detection in the Diagnosis of Infection after Allogeneic Hematopoietic Stem Cell Transplantation in Children |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
|
| 物种名称 |
human metagenome
|
| 描述信息 |
We compared metagenomic next-generation sequencing (mNGS) and traditional pathogen detection in investigating the pathogens of infections (such as bloodstream infections, pulmonary infections, and central nervous system (CNS) infections) in pediatric allo-HSCT recipients. This study retrospectively analyzed 101 pediatric recipients of allo-HSCT, including 54 bronchoalveolar lavage fluid samples, 32 blood samples, and 15 cerebrospinal fluid samples. Eighty-seven were diagnosed with post-transplant infectious diseases and 14 with non-infectious diseases eventually. The sensitivity and specificity of mNGS were compared to traditional pathogen detection methods. |
| 样品范围 |
Multispecies |
| 发布日期 |
2022-04-22 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35509305
|
Metagenomic Next-Generation Sequencing vs. Traditional Pathogen Detection in the Diagnosis of Infection After Allogeneic Hematopoietic Stem Cell Transplantation in Children
|
Frontiers in Microbiology
|
10.3389/fmicb.2022.868160
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Clinical Applied Drug Research Fund of Guangdong Province
|
|
2020ZJ02
|
|
| Internal scientific research fund of the Institute of Pediatrics, Guangzhou Women and Children's Medical Center
|
|
YIP-2019-017
|
|
|
|
| 提交者 |
Ye
Zhang (zhangye@hugobiotech.com)
|
| 提交单位 |
Hugobiotech Beijing Co.,Ltd. |
| 提交日期 |
2022-02-22 |
