| 项目编号 |
PRJCA008473 |
| 项目标题 |
Palbociclib-based High-throughput Combination Drug Screening Identifies Synergistic Therapeutic Options in HPV-negative Head and Neck Squamous Cell Carcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Deregulation of cell-cycle pathway is ubiquitously observed in human papillomavirus negative (HPVneg) head and neck squamous cell carcinoma (HNSCC). Despite being an attractive target, CDK4/6 inhibition using palbociclib showed modest or conflicting results as monotherapy or in combination with platinum-based chemotherapy or cetuximab in HPVneg HNSCC. Thus, innovative agents to augment the efficacy of palbociclib in HPVneg HNSCC would be welcomed.This study provides insights into the systematic combinatory effects associated with CDK4/6 inhibition and supports further initiation of clinical trials using the palbociclib plus alpelisib combination in HPVneg HNSCC with PIK3CA alterations. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2022-02-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 35546399
|
Palbociclib-based high-throughput combination drug screening identifies synergistic therapeutic options in HPV-negative head and neck squamous cell carcinoma
|
BMC Medicine
|
10.1186/s12916-022-02373-6
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Shanghai Clinical Research Center for Oral Diseases
|
|
19MC1910600
|
|
|
|
| 提交者 |
zhiyaun
Zhang (zhiyuan.zhang@sh9hospital.org.cn)
|
| 提交单位 |
Shanghai Jiaotong University School of Medicine |
| 提交日期 |
2022-02-28 |
