| Accession |
PRJCA008531 |
| Title |
Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer |
| Relevance |
Medical |
| Data types |
Genome sequencing and assembly
|
| Organisms |
Homo
|
| Description |
Through microRNA deep sequencing and microRNA-chip array, we found 4 prospective EV-delivered miRNAs including miR-181a-5p with significantly upregulated expression in bone metastatic groups than in non-bone metastatic prostate cancer groups (p < 0.05). In the validation cohorts, logistic regression analysis was performed to evaluate the diagnostic association of candidates with bone metastasis, which indicated that miR-181a-5p was significantly associated with bone metastatic prostate cancer. Furthermore, accuracy estimate of each candidate for the diagnosis of bone metastatic prostate cancer was quantified using the area under the receiver-operating characteristic curve (AUC), which identified miR-181a-5p as the best biomarker with the AUCs of 85.6% for diagnosis of prostate cancer and 73.8% for diagnosis of bone metastatic prostate cancer. |
| Sample scope |
Environment |
| Release date |
2022-03-03 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81874097-YXF
|
|
|
|
| Submitter |
Weiqiang
Gao (gao.weiqiang@sjtu.edu.cn)
|
| Organization |
Shanghai Jiao Tong University |
| Submission date |
2022-03-03 |
