| Accession |
PRJCA008590 |
| Title |
Single cell dissection of bronchoalveolar immune cells in patients with checkpoint inhibitor-related pneumonitis |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| Organisms |
Homo sapiens
Homo
|
| Description |
Immune checkpoint inhibitors (ICIs) therapy induced pneumonitis (CIP) complicates this effective therapy in patients with non-small cell lung cancer (NSCLC) and makes it difficult to classify from other pneumonitis. Comprehensively dissecting the key cellular players and molecular pathways associated with CIP pathobiology is critical for precision diagnosis and develop novel therapy strategy of CIP. Here, we implemented comprehensive single-cell transcriptome, flow cytometry and cytokine expression analysis to shed light on the complexity of the immunological responses in the bronchoalveolar microenvironment from NSCLC patients with CIP. |
| Sample scope |
Single cell |
| Release date |
2022-12-31 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37653115
|
Deciphering pathogenic cellular module at single-cell resolution in checkpoint inhibitor-related pneumonitis
|
Oncogene
|
10.1038/s41388-023-02805-4
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
the National Key R&D Program of China
|
2017YFC0907904
|
|
|
|
| Submitter |
Yi
Hu (huyi_0912@126.com)
|
| Organization |
the Fifth Medical Center of PLA General Hospital |
| Submission date |
2022-03-09 |
