| Accession |
PRJCA008621 |
| Title |
Lineage Reprogramming of Fibroblasts into Functional Neurons and Hepatocytes via Chemically Induced XEN-like State |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
Direct lineage reprogramming has emerged as a promising approach for generating desired cell types. We found that chemically induced XEN-like cells can be induced during chemical induction of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here, we show that these chemically induced XEN-like cells can also be induced to directly reprogram into functional hepatocytes and neurons, bypassing the pluripotent state. |
| Sample scope |
Multiisolate |
| Release date |
2023-12-14 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2017YFA0104000
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2016YFA0100103
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31521004
|
|
|
|
| Submitter |
Hongkui
Deng (hongkui_deng@pku.edu.cn)
|
| Organization |
Peking University |
| Submission date |
2022-03-11 |
