| 项目编号 |
PRJCA008838 |
| 项目标题 |
Single-cell RNA-sequencing reveals tumor heterogeneity in adamantinomatous craniopharyngiomas |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Adamantinomatous craniopharyngioma (ACP) is a rare brain tumor that occurs in the sellar region. The specific location and aggressive growth pattern of ACP result in a poor prognosis. However, the cellular composition of ACP and the molecular mechanisms involved in ACP tumorigenesis and progression remain unclear. This study aims to comprehensively characterize the tumor heterogeneity landscape and tumor microenvironment of ACP based on single-cell RNA-sequencing (scRNA-seq) and provide a basis for the improvement of clinical treatment strategies. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-04-05 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 37043580
|
Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma
|
Science Advances
|
10.1126/sciadv.adc8933
|
2023
|
| 41250940
|
A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery
|
Advanced Science
|
10.1002/advs.202503924
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82173175
|
|
|
|
| 提交者 |
Jianguo
Xu (xujg@scu.edu.cn)
|
| 提交单位 |
West China Hospital Sichuan University |
| 提交日期 |
2022-03-25 |
