| 项目编号 |
PRJCA009109 |
| 项目标题 |
Molecular Characteristics Correlated with Immunotherapy Efficacy in Gastrointestinal Cancers |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This study examines the molecular characteristics linked to the efficacy of immunotherapy in gastrointestinal (GI) cancers by analyzing whole-exome sequencing data from the JUPITER-06 cohort and RNA sequencing data from the Capability-01 cohort. JUPITER-06 Cohort: Patient data were sourced from the JUPITER-06 prospective clinical trial, which evaluated the efficacy of chemotherapy in combination with the PD-1 antibody Toripalimab. Formalin-fixed paraffin-embedded (FFPE) tumor tissues and peripheral blood samples (for germline control) were collected prior to the initiation of therapy. Genomic analyses were performed on the collected tissue samples. This cohort encompasses 95% of the total patient population enrolled in the JUPITER-06 trial. Capability-01 Cohort: Patient data were obtained from the Capability-01 prospective clinical trial, which assessed the efficacy of a novel triplet therapy comprising a PD-1 antibody, the HDAC inhibitor Chidamide, and the VEGF antibody Bevacizumab. To elucidate the underlying mechanisms contributing to the clinical effectiveness of this triplet therapy, paired biopsy samples of tumor tissue were collected both prior to treatment (n = 10) and post-treatment (n = 10). RNA sequencing was performed on these samples, with data derived from the doublet arm including 6 patients and from the triplet arm including 4 patients. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-08-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 37059106
|
An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma
|
Cancer Cell
|
10.1016/j.ccell.2023.03.016
|
2023
|
| 38438735
|
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
|
Nature Medicine
|
10.1038/s41591-024-02813-1
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
The International Cooperation and Exchanges National Natural Science Foundation of China
|
82061160373
|
|
| Science and Technology Program of Guangdong
|
|
2019B020227002
|
|
| CAMS Innovation Fund for Medical Sciences (CIFMS)
|
|
2019-I2M-5-036
|
|
| Science and Technology Program of Guangzhou
|
|
202206080011
|
|
|
|
| 提交者 |
Rui-hua
Xu (xurh@sysucc.org.cn)
|
| 提交单位 |
Sun Yat-sen University |
| 提交日期 |
2022-04-12 |
