| 项目编号 |
PRJCA009122 |
| 项目标题 |
Single-cell RNA profiling and spatial transcriptomics of primary biliary cholangitis |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Primary biliary cholangitis is an autoimmune liver disease characterized by selective destructions of small- and medium-sized intrahepatic bile ducts. However, the reasons why PBC selectively targets these bile ducts and its underlying mechanisms are still largely unclear. In this study, liver samples from control and PBC patients were used for single-cell RNA sequencing and spatial transcriptomics to explore the pathogenesis of this disease. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-10-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36759512
|
Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis
|
Nature Communications
|
10.1038/s41467-022-34606-w
|
2023
|
|
|
| 实验材料提供者 |
Department of Gastroenterology, Center for Metabolic Associated Fatty Liver Disease and Center for Cholestatic Liver Diseases, The First Affiliated Hospital (Southwest Hospital), Third Military Medical University (Army Medical University) |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
31971086
|
Effect and mechanism of Cholic acid secreting protein OATP3A1 on cholestatic bile duct injury
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
81770583
|
Study on pathogenesis and treatment of cholestatic liver disease
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81922012
|
The mechanism of high IL-32 expression in cholestasis promoting liver inflammatory amplification and liver fibrosis
|
|
|
| 提交者 |
Xi
Li (lixi1988xn@163.com)
|
| 提交单位 |
Southwest Hospital of AMU |
| 提交日期 |
2022-04-14 |
