| Accession |
PRJCA009122 |
| Title |
Single-cell RNA profiling and spatial transcriptomics of primary biliary cholangitis |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Primary biliary cholangitis is an autoimmune liver disease characterized by selective destructions of small- and medium-sized intrahepatic bile ducts. However, the reasons why PBC selectively targets these bile ducts and its underlying mechanisms are still largely unclear. In this study, liver samples from control and PBC patients were used for single-cell RNA sequencing and spatial transcriptomics to explore the pathogenesis of this disease. |
| Sample scope |
Single cell |
| Release date |
2022-10-04 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36759512
|
Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis
|
Nature Communications
|
10.1038/s41467-022-34606-w
|
2023
|
|
|
| Biomaterial provider |
Department of Gastroenterology, Center for Metabolic Associated Fatty Liver Disease and Center for Cholestatic Liver Diseases, The First Affiliated Hospital (Southwest Hospital), Third Military Medical University (Army Medical University) |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
31971086
|
Effect and mechanism of Cholic acid secreting protein OATP3A1 on cholestatic bile duct injury
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
81770583
|
Study on pathogenesis and treatment of cholestatic liver disease
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81922012
|
The mechanism of high IL-32 expression in cholestasis promoting liver inflammatory amplification and liver fibrosis
|
|
|
| Submitter |
Xi
Li (lixi1988xn@163.com)
|
| Organization |
Southwest Hospital of AMU |
| Submission date |
2022-04-14 |
