| Accession |
PRJCA009226 |
| Title |
Transcriptome sequencing of ischemic tissue in stroke mouse after DNT treatment |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
To verify the influence of double negative T cell (DNT) treatment on ischemic stroke mice, we investigate the transcriptional profile of infarct tissue after DNT treatment. A preclinical mouse model, occlusion of the distal branches of the middle cerebral artery (dMCAO), displays key features of human ischemic stroke. In this study, we adoptive transferred intravenously to ischemic stroke mice after 30 minutes of dMCAO. Infarct foci were isolated from ischemic stroke mice after 12 hours and 1, 3, 7, 14, 21 days. RNAs were obtained from infarct tissues and sequenced using a standard Illumina protocol. |
| Sample scope |
Multiisolate |
| Release date |
2023-04-20 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36793857
|
TCRαβ+NK1.1-CD4-CD8- double-negative T cells inhibit central and peripheral inflammation and ameliorate ischemic stroke in mice
|
Theranostics
|
10.7150/thno.80307
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82171823
|
|
|
|
| Submitter |
Dan
Tian (tiand@ccmu.edu.cn)
|
| Organization |
Beijing Friendship Hospital, Capital Medical University |
| Submission date |
2022-04-20 |
