| Accession |
PRJCA009482 |
| Title |
Mechanism of intercellular protein homeostasis regulation |
| Relevance |
Model organism |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
mass spectrometric data
|
| Organisms |
Caenorhabditis elegans
|
| Description |
The protein homeostasis is regulated at multiple scales, not limited at the cellular level. In eukaryotic cells, elaborate signaling pathways are evolved in Mitochondria (Mito) and Endoplasmic Reticulum (ER) to maintain the protein homeostasis. Disturbance of such homeostasis results in misfolded proteins accumulation in these organelles, and trigger adaptive response termed the Unfolded Protein Response (UPR) in order to cope with the challenge. Much work has been done to understand the UPR in Mito and ER, however, how Mito- and ER-UPR function across multiple cells and tissues coordinately to deal with the stress in the organism is largely unknown. Here we propose to study the molecular mechanism of cell non-autonomous UPR by using C. elegans and mammalian cell culture system. We anticipate a better understanding of the protein homeostasis at the multicellular level, and to provide new therapeutic strategies for related diseases such as aging, neurodegenerative diseases and cancer. |
| Sample scope |
Monoisolate |
| Release date |
2022-05-10 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 34341532
|
|
|
|
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2017YFA0506400
|
Mechanism of intercellular protein homeostasis regulation
|
|
|
| Submitter |
Xueying
Wu (xueyingwu@genetics.ac.cn)
|
| Organization |
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences |
| Submission date |
2022-05-09 |
