| 项目编号 |
PRJCA009524 |
| 项目标题 |
Chemotherapy-Induced Remodeling of Breast Cancer Revealed by Single-Cell RNA Sequencing |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The transcriptomes and spatial distribution patterns of cancer cells and immune cells from paired HR+ BC samples pre- and post-NAC were characterized with single-cell RNA sequencing (N=8) and multiplexed immunofluorescence staining (N=21). Our data shed light on the microenvironment of HR+ BC reshaped by chemotherapy, identified candidates for predicting chemosensitivity and implied potential strategies for increasing the response rate of HR+ BC |
| 样品范围 |
Single cell |
| 发布日期 |
2024-05-11 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82073151
|
Modulation of N2 polarization induced by STAT3 axis in tamoxifen-resistant breast cancer and its positive feedback mechanism
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82173089
|
Mechanism and immune intervention of CD8 + T cell depletion induced by radiotherapy in head and neck tumors
|
|
|
| 提交者 |
Chao
Ni (davenc@163.com)
|
| 提交单位 |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2022-05-11 |
