| 项目编号 |
PRJCA009690 |
| 项目标题 |
Single-Cell Characterization Identified the Origin and Novel Classification of Pituitary Neuroendocrine Tumors |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Pituitary neuroendocrine tumor (PitNET), which occurs in anterior pituitary gland (APG), is one of the most common intracranial tumors. The origin and differentiation degree of other neuroendocrine tumor are important for clinical decision-making. Due to high heterogeneity in APG, the underlying origin of PitNET remains unclear. Using single-cell RNA sequencing, we generated the transcriptomes of 6,589 APG cells from 3 adults, and those of 58,348 PitNET cells from 21 patients. An Origin-Based (OB) classification was established to estimate the origin and differentiation degreestatus of PitNET. We identified activation of diverse hormone-secreting related pathways in well differentiated PitNETs, including three prolactin secretion patterns. In poorly differentiated PitNETs, lipid metabolism dysregulation was common. Further validation showed that OB classification could predict prognosis in an independent cohort of 423 PitNETs with an average follow-up of 7.1 years. Our findings provide insight into the developmental trajectories and differentiation status underlying PitNET initiation and progression. |
| 样品范围 |
Single cell |
| 发布日期 |
2022-11-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40442104
|
Single-cell and spatial transcriptome analyses reveal tumor heterogeneity and immune remodeling involved in pituitary neuroendocrine tumor progression
|
Nature Communications
|
10.1038/s41467-025-60028-5
|
2025
|
| 40813692
|
PIT-1/SF-1-positive pituitary tumors in patients with acromegaly: transcriptomic perspective
|
Acta Neuropathologica Communications
|
10.1186/s40478-025-02091-z
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Joint Funds program
|
U21A20389
|
|
| Chinese Academy of Medical Sciences
|
Innovation Fund for Medical Sciences
|
2021-I2M-C&T-A-025
|
|
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
81725011
|
|
| National Ten Thousand Talents Program
|
Top-Notch Young Professionals
|
to-Yao-Zhao
|
|
| The Chang Jiang Scholars Program
|
|
to-Yao-Zhao
|
|
| Shanghai Chenguang Scholar
|
|
19CG08
|
|
|
|
| 提交者 |
Yao
Zhao (zhaoyaohs@vip.sina.com)
|
| 提交单位 |
Huashan Hospital of Fudan University |
| 提交日期 |
2022-05-21 |
