| 描述信息 |
Pituitary neuroendocrine tumor (PitNET), which occurs in anterior pituitary gland (APG), is one of the most common intracranial tumors. The origin and differentiation degree of other neuroendocrine tumor are important for clinical decision-making. Due to high heterogeneity in APG, the underlying origin of PitNET remains unclear. Using single-cell RNA sequencing, we generated the transcriptomes of 6,589 APG cells from 3 adults, and those of 58,348 PitNET cells from 21 patients. An Origin-Based (OB) classification was established to estimate the origin and differentiation degreestatus of PitNET. We identified activation of diverse hormone-secreting related pathways in well differentiated PitNETs, including three prolactin secretion patterns. In poorly differentiated PitNETs, lipid metabolism dysregulation was common. Further validation showed that OB classification could predict prognosis in an independent cohort of 423 PitNETs with an average follow-up of 7.1 years. Our findings provide insight into the developmental trajectories and differentiation status underlying PitNET initiation and progression. |
