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Accession PRJCA009779
Title Cytoarchitectonic atlas of the human cerebral cortex
Relevance Model organism
Data types Transcriptome or Gene expression
Single cell sequencing
Organisms Homo sapiens
Description Charting the cellular diversity and architecture of the human brain holds the key to elucidating human intelligence. To construct a transcriptomic cell-type taxonomy and cytoarchitectural atlas, we profiled the transcriptomes of 307,738 cells and 46,948 spatial spots across the entire adult human cerebral cortex. The atlas revealed significant expression patterns and spatial arrangement heterogeneity between cell types. There were found to be strong correlations between spatial arrangements, molecular characteristics, developmental origin, and cellular functions. In contrast to GABAergic neurons, glutamatergic neurons were found to be highly specific in both laminar and regional distribution, and their expression pattern was similar in adjacent cortical regions. Moreover, the atlas was utilized to precisely locate layer 4 and investigate a subplate structure known as layer 6b, revealing specific marker genes and cellular composition. Together, our work deciphered the cytoarchitecture of the human cortex, shedding light on the cellular basis of complex intelligent regions.
Sample scope Single cell
Release date 2022-07-29
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) Major Program 62032007
National Natural Science Foundation of China (NSFC) Excellent Young Scientists Fund 61822108
Submitter Qinghua JIANG (qhjiang@hit.edu.cn)
Organization Harbin Institute of Technology
Submission date 2022-05-29

Project Data

Resource name Description
BioSample (42)  show -