Accession PRJCA009794
Title A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
Relevance Medical
Data types Transcriptome or Gene expression
Single cell sequencing
Organisms Mus musculus
Description Exercise is generally considered to have beneficial effects on the body, including improving tissue homeostasis, promoting regeneration, and improving disease resistance. But this effect has not been studied at multi-tissue, single-cell resolution, nor has it been carefully examined in young and old individuals. In order to systematically study the effects of exercise on multiple tissues and organs of the body, especially the effects on neural, immune, vascular, and stem cells, we performed aerobic exercise in young and old mice, and evaluated in detail at the single-cell level the changes in cell composition and gene expression of 14 different tissues and organs including brain, heart, muscle, liver, and kidney. We also treated exercised and non-exercise mice with the pro-inflammatory bacterial lipopolysaccharide, aiming to reveal the effect of exercise on pro-inflammatory injuries at single cell resolution.
Sample scope Monoisolate
Release date 2023-01-06
Publication
PubMed ID Article title Journal name DOI Year
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body The Innovation 10.1016/j.xinn.2023.100380 2023
36747595 A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body The Innovation 10.1016/j.xinn.2023.100380 2023
Grants
Agency program Grant ID Grant title
No funding support
Submitter Guanghui Liu (ghliu@ioz.ac.cn)
Organization Institute of Zoology, Chinese Academy of Sciences
Submission date 2022-05-30

Project Data

Resource name Description
BioSample (330)  show -
GSA (1) -
CRA007207 A Single-cell Transcriptomic Atlas of Exercise-induced Anti-inflammatory and Geroprotective Effects across the Body