项目编号 PRJCA009794
项目标题 A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
涉及领域 Medical
数据类型 Transcriptome or Gene expression
Single cell sequencing
物种名称 Mus musculus
描述信息 Exercise is generally considered to have beneficial effects on the body, including improving tissue homeostasis, promoting regeneration, and improving disease resistance. But this effect has not been studied at multi-tissue, single-cell resolution, nor has it been carefully examined in young and old individuals. In order to systematically study the effects of exercise on multiple tissues and organs of the body, especially the effects on neural, immune, vascular, and stem cells, we performed aerobic exercise in young and old mice, and evaluated in detail at the single-cell level the changes in cell composition and gene expression of 14 different tissues and organs including brain, heart, muscle, liver, and kidney. We also treated exercised and non-exercise mice with the pro-inflammatory bacterial lipopolysaccharide, aiming to reveal the effect of exercise on pro-inflammatory injuries at single cell resolution.
样品范围 Monoisolate
发布日期 2023-01-06
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body The Innovation 10.1016/j.xinn.2023.100380 2023
36747595 A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body The Innovation 10.1016/j.xinn.2023.100380 2023
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
No funding support
提交者 Guanghui Liu (ghliu@ioz.ac.cn)
提交单位 Institute of Zoology, Chinese Academy of Sciences
提交日期 2022-05-30

项目包含数据信息

资源名称 描述
BioSample (330)  show -
GSA (1) -
CRA007207 A Single-cell Transcriptomic Atlas of Exercise-induced Anti-inflammatory and Geroprotective Effects across the Body