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项目编号 PRJCA009862
项目标题 Spatial transcriptomic analyses of NSCLC
涉及领域 Medical
数据类型 Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
物种名称 Homo sapiens
描述信息 PD-(L)1 immune checkpoint inhibitors have shifted the treatment paradigm of advanced non-small cell lung cancer (NSCLC). Here, we combined single cell and spatial transcriptomics to identify the spatial landscape of the NSCLC tumor microenvironment (TME) during immunotherapy. Multidimensional bioinformatics analyses revealed distinct spatial compartmentalization of the TME. Our study provides novel insights into the complex spatiotemporal ecosystem of NSCLC and offers clues for combinational therapies.
样品范围 Single cell
发布日期 2024-01-01
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
39658657 Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer Nature Genetics 10.1038/s41588-024-01998-y 2025
40777001 Immunotherapy enhances the risk of tumor oxidative stress and metastasis in lung cancer with radiation pneumonitis Frontiers in Immunology 10.3389/fimmu.2025.1629170 2025
40799444 Single-cell and spatial transcriptomics profile the interaction of SPP1 + macrophages and FAP + fibroblasts in non-small cell lung cancer Peer Review File Translational Lung Cancer Research 10.21037/tlcr-2025-244 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 81972172
提交者 Peng Zhang (zhangpeng1121@tongji.edu.cn)
提交单位 Shanghai Pulmonary Hospital Tongji University
提交日期 2022-02-22

项目包含数据信息

资源名称 描述
BioSample (46)  show -