| 项目编号 |
PRJCA009905 |
| 项目标题 |
A living biobank of matched pairs of patient-derived xenografts and organoids |
| 涉及领域 |
Medical |
| 数据类型 |
Exome
Transcriptome or Gene expression
Variation
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| 物种名称 |
Mus musculus
|
| 描述信息 |
Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensively to test various investigational therapies, including population trials as surrogate subjects in vivo. PDOs are in vitro surrogates for patients amenable to high-throughput screening (HTS). We have built a biobank of carcinoma PDX-derived organoids (PDXOs) by converting an existing PDX library and confirmed a high degree of similarities between PDXOs and parental PDXs in genomics, histopathology, and pharmacology, suggesting biological equivalence or interchangeability between the two. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2022-06-07 |
| 出版信息 |
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| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
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| 提交者 |
Binchen
Mao (binchen.mao@crownbio.com)
|
| 提交单位 |
Crown Bioscience |
| 提交日期 |
2022-06-05 |
