| Accession |
PRJCA009905 |
| Title |
A living biobank of matched pairs of patient-derived xenografts and organoids |
| Relevance |
Medical |
| Data types |
Exome
Transcriptome or Gene expression
Variation
|
| Organisms |
Mus musculus
|
| Description |
Patient-derived tumor xenograft (PDX)/organoid (PDO), driven by cancer stem cells (CSC), are considered the most predictive models for translational oncology. Large PDX collections reflective of patient populations have been created and used extensively to test various investigational therapies, including population trials as surrogate subjects in vivo. PDOs are in vitro surrogates for patients amenable to high-throughput screening (HTS). We have built a biobank of carcinoma PDX-derived organoids (PDXOs) by converting an existing PDX library and confirmed a high degree of similarities between PDXOs and parental PDXs in genomics, histopathology, and pharmacology, suggesting biological equivalence or interchangeability between the two. |
| Sample scope |
Multiisolate |
| Release date |
2022-06-07 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
Binchen
Mao (binchen.mao@crownbio.com)
|
| Organization |
Crown Bioscience |
| Submission date |
2022-06-05 |
