| 项目编号 |
PRJCA010424 |
| 项目标题 |
ScanTecc classifies primary cancers via cell-free extrachromosomal circular DNA in peripheral blood |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Extrachromosomal circular DNA (eccDNA) contributes to cancer progression, but its presence in cell-free plasma and utility as a non-invasive diagnostic biomarker in circulation remain poorly understood. In this study, we profiled plasma eccDNA from a large multi-cancer cohort. We found that plasma from cancer patients contains significantly higher levels of eccDNA and longer fragment lengths compared to healthy individuals. We also identified a tumor-specific eccDNA size threshold and developed a machine learning-based approach that utilizes eccDNA profiles to distinguish cancer patients from healthy individuals and classify cancer types with high accuracy. These results provide the feasibility of applying peripheral blood-derived eccDNA signatures for non-invasive cancer diagnosis. |
| 样品范围 |
peripheral blood of patients with tumors |
| 发布日期 |
2025-06-17 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
National Science Funds for Distinguished Young Scholars
|
T2125012
|
|
|
|
| 提交者 |
Kun
Qu (qukun@ustc.edu.cn)
|
| 提交单位 |
University of Science and Technology of China |
| 提交日期 |
2022-07-06 |
