| Accession |
PRJCA010787 |
| Title |
Adenosine deaminase 2 as a biomarker for head and neck cancers in saliva |
| Relevance |
Medical |
| Data types |
saliva
|
| Organisms |
Homo sapiens
|
| Description |
To further increase the sensitivity of ADA2 detection, we developed an ELISA in which we used polyclonal antibodies to capture and detect ADA2. The use of ADA1 instead of HRP as a detection enzyme permits analyzing the samples with a broad ADA2 concentration. We developed a saliva sampling and storage protocol.Some publications indicated that ADA activity is different in healthy controls and patients with oral cancers, though the results are contradictory. We collected and analyzed saliva from head and neck cancer patients. Careful analysis showed that the enzyme's concentration depends on the type of cancer . This observation could be explained by the difference in the severity of the disease . |
| Sample scope |
saliva |
| Release date |
2022-07-25 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
ELISA based assays to measure adenosine deaminases concentration in serum and saliva for the diagnosis of ADA2 deficiency and cancer
|
Frontiers in Immunology
|
10.3389/fimmu.2022.928438
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| AZ starting up Grant
|
other
|
3001065
|
|
|
|
| Submitter |
Wenwen
Luo (luoww@stu.gzhmu.edu.cn)
|
| Organization |
Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China |
| Submission date |
2022-07-25 |
