| Accession | PRJCA010807 | ||||||||||||||||||||||||||||||||||||||||||||||||
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| Title | Spatiotemporal landscape of hepatocellular carcinoma auto-driven ecosystems | ||||||||||||||||||||||||||||||||||||||||||||||||
| Relevance | Medical | ||||||||||||||||||||||||||||||||||||||||||||||||
| Data types |
Whole genome sequencing
Exome Transcriptome or Gene expression Single cell sequencing |
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| Organisms | Homo sapiens | ||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Intertumoral heterogeneity (ITH) is the greatest challenge in hepatocellular carcinoma (HCC) treatment, whereas elucidation of the spatial-temporal features remain extremely limited. We profiled dynamic single cell-spatial-bulk transcriptome landscapes from six HCC cases and a non-carcinoma liver control donor. We found that ITH mainly derived from HCC cells diversity and pervaded the genome-transcriptome-proteome-metabolome life network. HCC cells is the core driving force of tumor evolution, dominantly tame tumor-associated macrophages to initiate cascaded regulations of immune micro-environment. Specifically, M1-types were characterized by disturbance of metabolism, poor antigen-presentation and immune-killing abilities. Remarkably, simultaneous cirrhotic and HCC lesions in a individual patient shared a common origin and displayed parallel clone evolution, that driving immune reprogram for enhancement of better environmental adaptiveness. Moreover, endothelial cells were phenotypically conserved but executed differential functions in a space-dependent manner. Our data unravels the great significance of HCC cells in shaping vibrant tumor ecosystems corresponding to specific clinical scenarios. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sample scope | Single cell | ||||||||||||||||||||||||||||||||||||||||||||||||
| Release date | 2022-07-26 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Grants |
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| Submitter | Rong Liang (liangrong@gxmu.edu.cn) | ||||||||||||||||||||||||||||||||||||||||||||||||
| Organization | Guangxi Medical University Cancer Hospital | ||||||||||||||||||||||||||||||||||||||||||||||||
| Submission date | 2022-07-26 |
| Resource name | Description |
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| BioSample (8) show | - |