| Accession |
PRJCA010927 |
| Title |
prevalence and landscape of germline mutations in Chinese patients with gastrointestinal cancers |
| Relevance |
Medical |
| Data types |
Targeted Locus (Loci)
Variation
|
| Organisms |
Homo sapiens
|
| Description |
Tumor-normal sequencing with a multi-gene panel in unselected oncology patients can identify germline findings with potential clinical utility that may be missed by guideline-based genetic testing. Our study aimed to interrogate the prevalence and landscape of germline pathogenic/ likely pathogenic (P/LP) mutations in a large cohort of unselected Chinese patients with gastrointestinal (GI) cancers. In basis of the mutation spectrum of diverse digestive system tumors, we will highlight the clinical implication of germline testing with a multigene panel as for risk assessment, prevention and therapeutic decision-making in patients with GI cancers regardless of family history and histopathological diagnosis. |
| Sample scope |
Multiisolate |
| Release date |
2022-08-01 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| No funding support
|
|
|
|
|
|
| Submitter |
lin
shen (linshenpku@163.com)
|
| Organization |
Beijing Cancer Hospital |
| Submission date |
2022-08-01 |
