| Accession |
PRJCA011037 |
| Title |
Tumor immune microenvironment and immunotherapy efficacy in BRAF mutation non-small-cell lung cancer |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Previous small size studies reported BRAF mutated NSCLC patients have comparable sensitivity to immune checkpoint inhibitors (ICIs). However, how BRAF mutation affects the tumor immune microenvironment (TIME) of NSCLC is unknown. We performed Nanostring-panel RNA sequencing to evaluate TIME in 57 BRAF mutated and wild-type (WT) NSCLC specimens. We found that BRAF-mutant tumors had similar ratios of CD8+ T cells to Tregs, the balance of a cytotoxicity gene expression signatures and immune suppressive features, and similar ICI-response-related biomarkers to WT NSCLC. Further, we found that a similar pattern of TIME was observed between the BRAF V600E and non-V600E subgroups of NSCLC. |
| Sample scope |
Multiisolate |
| Release date |
2022-08-07 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36543792
|
Tumor immune microenvironment and immunotherapy efficacy in BRAF mutation non-small-cell lung cancer
|
Cell Death & Disease
|
10.1038/s41419-022-05510-4
|
2022
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Beijing Xisike Clinical Oncology Research Foundation
|
|
Y-XD202002-0251
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81972718
|
|
| Natural Science Foundation of Zhejiang Province
|
|
LY22H160037
|
|
| the Science and Technology Program for Health and Medicine in Zhejiang Province
|
|
2021KY541
|
|
|
|
| Submitter |
Hui
Li (11118029@zju.edu.cn)
|
| Organization |
Zhejiang Cancer Hospital |
| Submission date |
2022-08-06 |
