| 项目编号 |
PRJCA011074 |
| 项目标题 |
ATAC-seq, RNA-seq and ChIP-seq data of high-risk pediatric B-lineage acute lymphoblastic leukemia |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The molecular mechanism of relapse remains unclear for around half of the pediatric B-lineage acute lymphoblastic leukemia (B-ALL). Here, we interpreted the chromatin accessibility features of 61 relapsed B-ALL patients by incorporating whole-genome sequencing (WGS), transcriptome sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) data. We showed the increased and rewired chromatin accessibility in B-ALL compared with normal B cells, which were associated with leukemogenesis. By analyzing for differential chromatin accessibility regions between diagnosis and relapse, we identified alterations in chromatin accessibility in response to drug treatment and those associated with relapse free survival. These data provide an integrative portrait of a pediatric B-ALL genome and emphasize the importance of chromatin accessibility alterations in tumorigenesis and drug responses. Totally, the new data set includes 79 ATAC-seq data, 37 RNA-seq data and 24 H3K27ac ChIP-seq data. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-09-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 37880218
|
Chromatin accessibility landscape of relapsed pediatric B-lineage acute lymphoblastic leukemia
|
Nature Communications
|
10.1038/s41467-023-42565-z
|
2023
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
31970627
|
|
|
|
| 提交者 |
Yu
Liu (liuyu@scmc.com.cn)
|
| 提交单位 |
Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine |
| 提交日期 |
2022-08-08 |
