| Accession |
PRJCA011382 |
| Title |
Single-cell RNA sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Radiochemotherapy (RCT) is a powerful treatment for cervical cancer, which affects not only malignant cells but also the immune and stromal compartments of the tumor. Understanding the remodeling of the local ecosystem induced by RCT would provide valuable insights into improving treatment strategies for cervical cancer. In this study, we applied single-cell RNA sequencing to paired pre- and post-RCT tumor biopsies from patients with cervical cancer and adjacent normal cervical tissues. |
| Sample scope |
Single cell |
| Release date |
2023-06-06 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36710358
|
Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer
|
Signal Transduction and Targeted Therapy
|
10.1038/s41392-022-01264-9
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Chinese Academy of Sciences (CAS)
|
|
2019RU071
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82030082
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81871895
|
|
|
|
| Submitter |
Chao
Liu (charles.liu@whu.edu.cn)
|
| Organization |
Shandong Cancer Hospital and Institute |
| Submission date |
2022-08-23 |
