| 项目编号 |
PRJCA011404 |
| 项目标题 |
Squalene epoxidase-catalyzed 24(S),25-epoxycholesterol promotes trained immunity-mediated antitumor activity |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
To generally investigate how the inhibition or knockout of SQLE affect β-glucan induced trained immunity, we had processed RNA seq after first stimulation and secondary stimulation, and ATAC-seq before secondary stimulation. RNA-seq after first stimulation could reflect the change of genes and pathways after β-glucan training or SQLE inhibition or deficiency. These changes would trigger the subsequent metabolic changes and epigenetic rewiring. ATAC-seq before secondary stimulation revealed the chromatin accessibility of genes related to inflammatory response, immune response and metabolic process. The accessibility would determine the intensity of secondary response. Thus, RNA-seq after secondary stimulation would verify the status of trained immunity. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-04-07 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38613784
|
Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
|
Cell Reports
|
10.1016/j.celrep.2024.114094
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2021YFC2400600
|
|
|
|
| 提交者 |
Xiaojun
Xia (xiaxj@sysucc.org.cn)
|
| 提交单位 |
Sun Yat-sen University Cancer Center |
| 提交日期 |
2022-08-23 |
