| 项目编号 |
PRJCA011516 |
| 项目标题 |
METTL3/METTL14 Regulate Biosynthesis of Key Cell Organelles in Human Embryonic Stem Cells |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Here we show that deletion of METTL3 or METTL14 in human embryonic stem cells (hESCs) leads to uncoupling pluripotency gene network from self-renewal. METTL3-/- or METTL14-/- hESCs lost self-renewal but well maintain the expression of typical pluripotency gene network. In contrast, the key cell organelles such as mitochondrial, proteasome, lysosome etc. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-07-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39169036
|
METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation
|
Nature Communications
|
10.1038/s41467-024-51742-7
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2017YFA0102600
|
|
|
|
| 提交者 |
Yongli
Shan (shan_yongli@gibh.ac.cn)
|
| 提交单位 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| 提交日期 |
2022-08-29 |
