项目编号 PRJCA011564
项目标题 Landscape of Potentially Targetable Receptor Tyrosine Kinase Fusions in Diverse Cancers by DNA-based Profiling
涉及领域 Medical
数据类型 Targeted Locus (Loci)
Genome sequencing
物种名称 Homo sapiens
描述信息 The genomic structures and corresponding partners of RTK fusions differed substantially according to cancer types. Cancer types, such as thyroid cancers, urological cancers and neuroendocrine tumors are selective in the RTK fusions they carry, while others exhibit highly complex spectrums of fusion events. Notably, most RTK genes were promiscuous in terms of the partner genes they recombine with. A large proportion of RTK fusions had one of the breakpoints localized to intergenic regions. Comprehensive genomic profiling revealed differences in co-mutational patterns pre- and post-TKI treatments across various RTK fusions.
样品范围 Multiisolate
发布日期 2024-08-31
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
36369474 Landscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profiling NPJ Precision Oncology 10.1038/s41698-022-00325-0 2022
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
No funding support
提交者 zhanhong chen (chzhanh3@mail.sysu.edu.cn)
提交单位 The Third Affiliated Hospital, Sun Yat-Sen University
提交日期 2022-08-31

项目包含数据信息

资源名称 描述
BioSample (1324)  show -