| 项目编号 | PRJCA011564 | ||||||||||
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| 项目标题 | Landscape of Potentially Targetable Receptor Tyrosine Kinase Fusions in Diverse Cancers by DNA-based Profiling | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Targeted Locus (Loci)
Genome sequencing |
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| 物种名称 | Homo sapiens | ||||||||||
| 描述信息 | The genomic structures and corresponding partners of RTK fusions differed substantially according to cancer types. Cancer types, such as thyroid cancers, urological cancers and neuroendocrine tumors are selective in the RTK fusions they carry, while others exhibit highly complex spectrums of fusion events. Notably, most RTK genes were promiscuous in terms of the partner genes they recombine with. A large proportion of RTK fusions had one of the breakpoints localized to intergenic regions. Comprehensive genomic profiling revealed differences in co-mutational patterns pre- and post-TKI treatments across various RTK fusions. | ||||||||||
| 样品范围 | Multiisolate | ||||||||||
| 发布日期 | 2024-08-31 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | zhanhong chen (chzhanh3@mail.sysu.edu.cn) | ||||||||||
| 提交单位 | The Third Affiliated Hospital, Sun Yat-Sen University | ||||||||||
| 提交日期 | 2022-08-31 |
| 资源名称 | 描述 |
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| BioSample (1324) show | - |