| Accession |
PRJCA011573 |
| Title |
Tissue-resident CXCL13+CD4+ T cells promote tertiary lymphoid structures formation, thereby improving the prognosis of early-stage lung adenocarcinoma |
| Relevance |
Medical |
| Data types |
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
we performed extensive transcriptional profiling of intratumoral immune infiltrates of 59 lung adenocarcinoma (LUAD) patients during the initiation and development processes of the premalignant lesion into lung cancer by massively parallel scRNA-seq of 63717 immune cells that passed quality control (QC) filtering, yielding profiles of 6475 B cells. More importantly, we reveal the differentiation trajectory of tumor-infiltrating B cells subsets and further explore the underlying mechanism of anti-tumor immunity. |
| Sample scope |
Single cell |
| Release date |
2023-11-01 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38458196
|
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure
|
Cell Reports Medicine
|
10.1016/j.xcrm.2024.101448
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
32170919
|
|
|
|
| Submitter |
Hanjie
Li (hj.li@siat.ac.cn)
|
| Organization |
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences |
| Submission date |
2022-08-31 |
