| Accession | PRJCA011678 | ||||||||||||||||
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| Title | NOVA1 in Adipogenesis | ||||||||||||||||
| Relevance | Medical | ||||||||||||||||
| Data types |
Epigenomics
Transcriptome or Gene expression Raw sequence reads |
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| Organisms |
Mus musculus
Homo sapiens |
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| Description | We found NOVA1, a neuron-specific RNA-binding protein, was specifically upregulated during the adipogenic induction of human white adipose tissue derived stromal/stem cells (hASCs). To explore its molecular roles in adipogenesis, hASCs were infected with shNOVA1 or the control lentiviral particles and then adipogenically induced for 3 days. The gene expressions of the cells were profiled using high density Affymetrix Human Transcriptome Arrays (HTA 2.0) and RNA-Seq. CLIP-Seq was applied to detecting the NOVA1-RNA interaction during white adipogenesis. ATAC-Seq was also performed to observe the effect of the interaction between NOVA1 and its target NCOR2 on the chromatin accessibility of hASCs. | ||||||||||||||||
| Sample scope | Multispecies | ||||||||||||||||
| Release date | 2023-08-15 | ||||||||||||||||
| Publication |
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| Grants |
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| Submitter | Ran Xiao (xiaoran@psh.pumc.edu.cn) | ||||||||||||||||
| Organization | Plastic Surgery Hospital, Chinese Academy of MedicalSciences & Peking Union Medical Collage | ||||||||||||||||
| Submission date | 2022-09-05 |