| Accession |
PRJCA011685 |
| Title |
RNA-seq analysis of skeletal muscle transcriptomes from wild-type and Fnip1 whole body knockout (FNIP1 KO) mice |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Mus musculus
|
| Description |
We generated FNIP1 KO and skeletal muscle specific FNIP1 transgenic mice (MCK-FNIP1 Tg). We also generated FNIP1 KO, PGC-1α f/f-MCK-Cre (DKO) and FNIP1 KO, AMPKα1/α2f/f-Myf5-Cre (TKO) mice, in which the PGC-1α or AMPKα1/α2 genes are disrupted in muscle in FNIP1 KO background. We then performed RNA-seq transcriptome analysis of muscles from WT, FINP1 KO, FNIP1 TgKO, DKO and TKO mice. Our data suggest that FNIP1 deficiency triggers muscle angiogenesis program through PGC-1α but not AMPK. |
| Sample scope |
Multiisolate |
| Release date |
2023-10-11 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37932296
|
FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment
|
Nature Communications
|
10.1038/s41467-023-42690-9
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
91857105
|
|
| National Natural Science Foundation of China (NSFC)
|
|
31922033
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32071136
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32100922
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0800700
|
|
|
|
| Submitter |
Zhenji
Gan (ganzj@nju.edu.cn)
|
| Organization |
Nanjing University |
| Submission date |
2022-09-05 |
