| Accession |
PRJCA011733 |
| Title |
scRNA-seq of T-ALL patients under CD7 CAR-T treatment |
| Relevance |
Medical |
| Data types |
Raw sequence reads
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
We obtained single-cell transcriptome profiles of the PBMCs from T-ALL patients before and after CD7 CAR-T cell treatment. By comparing these profiles, we built single-cell level transcriptome landscape of immune reconstruction and found the major functional influence on immune system of remove CD7 T-cells from PBMCs. |
| Sample scope |
Single cell |
| Release date |
2023-03-04 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36735547
|
Single-cell transcriptomics reveals immune reconstitution in R/R T-ALL/LBL patients with donor-derived CD7 CAR-T therapy
|
Clinical Cancer Research
|
10.1158/1078-0432.CCR-22-2924.
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
81970186
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82141113
|
|
|
|
| Submitter |
Wei
Chen (amurocw@hotmail.com)
|
| Organization |
Beihang University |
| Submission date |
2022-09-07 |
