| Accession | PRJCA012074 | ||||||||||
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| Title | Effects of different diets on the development of colorectal cancer in mice | ||||||||||
| Relevance | Model organism | ||||||||||
| Data types | Whole genome sequencing | ||||||||||
| Organisms |
Mus musculus
Bacteria |
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| Description | Colorectal cancer (CRC) is the third most common cancer in the world. With the improvement of people's living standards and the change of lifestyle, the incidence of colon cancer is increasing year by year. Therefore, it is of great significance to carry out active cancer prevention and treatment strategies to reduce the incidence and mortality of colorectal cancer. More and more studies have shown that different dietary intake will affect the occurrence and development of CRC. Western diet, especially high-fat diet, will increase the risk of colorectal cancer, while Mediterranean diet, ketogenic diet, vegetarian diet and restrictive diet can reduce the risk of colorectal cancer. Among them, whole grain intake may decrease the risk of CRC by increasing SCFA production by increasing beneficial gut microbes. Therefore, this study compared the effects of four different diets, including black rice, brown rice, white rice and control group, on the occurrence and development of colorectal cancer in mice. The results showed that black rice diet could slow down the occurrence and development of colorectal cancer by changing the composition of intestinal microbiota and regulating its metabolism. | ||||||||||
| Sample scope | stool | ||||||||||
| Release date | 2024-05-31 | ||||||||||
| Publication |
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| Grants |
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| Submitter | Yi-Xuan Tu (tuyx@webmail.hzau.edu.cn) | ||||||||||
| Organization | Huazhong Agricultural University | ||||||||||
| Submission date | 2022-09-22 |