| 项目编号 |
PRJCA012122 |
| 项目标题 |
Precision medicine of lung cancer using molecular probes in clinical translational study |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
our major aim of the study is to identify the subset of patients who may benefit from EGFR-TKIs therapy, and hence to design appropriate treatment strategies for optimized clinical outcome. Specifically, the biopsied samples of lung cancer patients are subjected to quantitative detection of EGFR mutations (L858R, 19del) using the fluorescent probe HX103 and FACS analysis. Combined with the results from gene sequencing and HX103 labeling, it will allow us to rapid and accurate determine EGFR mutations in lung cancer patients. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2022-09-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 36376325
|
A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations
|
Nature Communications
|
10.1038/s41467-022-34627-5
|
2022
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
92159302
|
|
| National Natural Science Foundation of China (NSFC)
|
|
91859203
|
|
| National Natural Science Foundation of China (NSFC)
|
|
21807076
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82104264
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82100119
|
|
| National Major Scientific and Technological Special Project
|
|
2018ZX09201018-021
|
|
| the Science and Technology Project of Sichuan Province
|
|
2022ZDZX0018
|
|
|
|
| 提交者 |
Li
Weimin (weimi003@scu.edu.cn)
|
| 提交单位 |
Frontiers Science Center for Disease-related Molecular Networks, West China Hospital, Sichuan University, Chengdu, Sichuan, China |
| 提交日期 |
2022-09-25 |
