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项目编号 PRJCA012320
项目标题 Whole-exome sequencing among Chinese patients with hereditary diffuse gastric cancer
涉及领域 Medical
数据类型 Exome
Targeted Locus (Loci)
物种名称 Homo sapiens
描述信息 E-cadherin (CDH1) and alpha-E-catenin gene (CTNNA1) were previously identified as hereditary diffuse gastric cancer (HDGC) susceptibility genes, explaining 25-50% of the HDGC cases. The genetic basis underlying disease susceptibility in the remaining 50-75% of HDGC patients is still illusive. Our study provided the genetic landscape for HDGC. We challenged the previous high germline mutation rate of CDH1 in HDGC and reported new potential susceptibility genes. Mutational signature and double-hit events analysis uncovered critical mechanism for HDGC tumorigenesis. The present study provided helpful information for the further investigations of HDGC.
样品范围 Multiisolate
发布日期 2024-10-06
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Key R&D Program of China 2018YFC1313300
National Natural Science Foundation of China (NSFC) 82073377
National Natural Science Foundation of China (NSFC) 81772587
National Natural Science Foundation of China (NSFC) 81972239
National Natural Science Foundation of China (NSFC) 82172861
Natural Science Foundation of Guangdong 2021A1515012439
Science and Technology Program of Guangdong 2019B020227002
CAMS Innovation Fund for Medical Sciences 2019-I2M-5-036
Program for Guangdong Introducing Innovative and Entrepreneurial Teams 2017ZT07S096
Tip-Top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program 2019TQ05Y351
Guangdong Basic and Applied Basic Research Foundation 2021A1515011743
Science and Technology Program of Guangzhou 202206080011
提交者 Rui-hua Xu (xurh@sysucc.org.cn)
提交单位 Sun Yat-sen University
提交日期 2022-10-06

项目包含数据信息

资源名称 描述
BioSample (539)  show -