| 项目编号 |
PRJCA012376 |
| 项目标题 |
Shanghai General Hospital Osteosarcoma Cohort |
| 涉及领域 |
Medical |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Osteosarcoma (OS) is the primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here we present the first large cohort of 121 OS patients from Shanghai General Hospital (SGH-OS Cohort), using hybrid-capture DNA sequencing, array-based DNA copy number, DNA methylation profiling and mRNA sequencing. Through integrating multi-omics data, we obtained a comprehensive genomic, epigenomic and transcriptomic landscape of OS and uncovered four distinct molecular subtypes with varied oncogenic factors. Moreover, we explored the diversity of clinical outcomes and the subtype-based targeted intervention that may influence OS clinical management. Our study provides a valuable insight into the biology of this disease, and a strong foundation of future precision medicine for each subtype that will eventually improve overall survival of osteosarcoma. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2022-11-01 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment
|
Nature Communications
|
10.1038/s41467-022-34689-5
|
2022
|
| 36418292
|
Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment
|
Nature Communications
|
10.1038/s41467-022-34689-5
|
2022
|
| 39983717
|
Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma
|
Cell Reports Medicine
|
10.1016/j.xcrm.2025.101977
|
2025
|
|
|
XGBoost-Based Prediction Model of High-Risk Osteosarcoma
|
JCO Precision Oncology
|
10.1200/PO-24-00732
|
2025
|
| 39962461
|
Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis
|
BMC Cancer
|
10.1186/s12885-025-13714-y
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| 提交者 |
Yingqi
Hua (yhua@shsmu.edu.cn)
|
| 提交单位 |
Shanghai bone tumor Institute, Shanghai General hospital, Shanghai Jiaotong University School of Medicine |
| 提交日期 |
2022-10-08 |
