| Accession |
PRJCA012616 |
| Title |
Proteomic Characterization of PAMs infected with PRRSV-ADE |
| Relevance |
Agricultural |
| Data types |
proteomics
|
| Organisms |
Sus scrofa
|
| Description |
to explore the proteomic characterization of primary alveolar macrophages (PAMs). we performed a TMT-based quantitative proteomic analysis of PAMs with PRRSV-ADE infection in this study. The results showed that a total of 3935 differentially expressed proteins (DEPs) were identified in PAMs infected with PRRSV-ADE, including 2004 up-regulated proteins and 1931 down-regulated proteins. Further, the Gene Ontology (GO) annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation and Protein-Protein Interaction (PPI) analysis for these DEPs have revealed that PRRSV-ADE infection might disturb the function of ribosome, proteasome and mitochondria. Interestingly, we also found that the most proteins of pattern recognition receptor (PRR)-mediated IFN signal pathways and antiviral proteins were significantly down-regulated. These alterations might be the critical factors to promote virus replication during the PRRSV-ADE infection. |
| Sample scope |
Monoisolate |
| Release date |
2022-12-15 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
|
|
Proteomic Characterization of PAMs with PRRSV-ADE Infection
|
Viruses
|
10.3390/v15010036
|
2022
|
|
|
Mass Spectrometry-Based Proteomic Analysis of Potential Host Proteins Interacting with GP5 in PRRSV-Infected PAMs
|
International Journal of Molecular Sciences
|
10.3390/ijms25052778
|
2024
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2022YFD1800043
|
the National Key Research & Development Program of China
|
| Henan Science and Technology Department
|
|
212300410353
|
the Natural Science Foundation of Henan Province
|
| Education Department of Henan
|
|
23A230004
|
the Key scientific research projects of colleges and universities in Henan Province
|
|
|
| Submitter |
Peng-li
Xu (xpl129012@163.com)
|
| Organization |
Henan Agricultural University |
| Submission date |
2022-10-19 |
