| 项目编号 |
PRJCA012616 |
| 项目标题 |
Proteomic Characterization of PAMs infected with PRRSV-ADE |
| 涉及领域 |
Agricultural |
| 数据类型 |
proteomics
|
| 物种名称 |
Sus scrofa
|
| 描述信息 |
to explore the proteomic characterization of primary alveolar macrophages (PAMs). we performed a TMT-based quantitative proteomic analysis of PAMs with PRRSV-ADE infection in this study. The results showed that a total of 3935 differentially expressed proteins (DEPs) were identified in PAMs infected with PRRSV-ADE, including 2004 up-regulated proteins and 1931 down-regulated proteins. Further, the Gene Ontology (GO) annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation and Protein-Protein Interaction (PPI) analysis for these DEPs have revealed that PRRSV-ADE infection might disturb the function of ribosome, proteasome and mitochondria. Interestingly, we also found that the most proteins of pattern recognition receptor (PRR)-mediated IFN signal pathways and antiviral proteins were significantly down-regulated. These alterations might be the critical factors to promote virus replication during the PRRSV-ADE infection. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2022-12-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Proteomic Characterization of PAMs with PRRSV-ADE Infection
|
Viruses
|
10.3390/v15010036
|
2022
|
|
|
Mass Spectrometry-Based Proteomic Analysis of Potential Host Proteins Interacting with GP5 in PRRSV-Infected PAMs
|
International Journal of Molecular Sciences
|
10.3390/ijms25052778
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2022YFD1800043
|
the National Key Research & Development Program of China
|
| Henan Science and Technology Department
|
|
212300410353
|
the Natural Science Foundation of Henan Province
|
| Education Department of Henan
|
|
23A230004
|
the Key scientific research projects of colleges and universities in Henan Province
|
|
|
| 提交者 |
Peng-li
Xu (xpl129012@163.com)
|
| 提交单位 |
Henan Agricultural University |
| 提交日期 |
2022-10-19 |
