| Accession |
PRJCA012759 |
| Title |
Transcriptomic analysis of clear cell renal cell carcinoma develops a prognostic classifier associated with thrombus |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Transcriptomic analysis identified 1130 tumorigenesis-associated significant differentially expressed genes (DEGs) and 856 invasion-associated DEGs in clear cell renal cell carcinoma. Overexpression of transcription factor EGR2 in venous tumor thrombus indicated its important role in tumor invasion. Furthermore, proteomic analysis showed 597 tumorigenesis-associated significant differentially expressed proteins (DEPs) and 508 invasion-associated DEPs. These detected invasion-associated DEPs showed unique enrichment in DNA replication, lysine degradation, and PPAR signaling pathway. Integration of transcriptome and proteome reveals 142 tumorigenesis-associated proteins and 84 invasion-associated proteins displaying abundance changes consistent with corresponding genes in transcriptomic profiling. Based on their different expression patterns among normal-carcinoma-thrombus triples, RAB25 and GGT5 were supposed to play a consistent role in both tumorigenesis and invasion processes, while SHMT2 and CADM4 might play the opposite role in tumorigenesis and thrombus invasion. A prognostic classifier consisting of six DEGs highly associated with survival (DEPTOR, DPEP1, NAT8, PLOD2, SLC7A5, SUSD2) performed satisfactorily in predicting survival of clear cell renal cell carcinoma patients (HR=4.41, P<0.001). |
| Sample scope |
Multiisolate |
| Release date |
2022-10-31 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 37328520
|
Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus
|
Scientific Reports
|
10.1038/s41598-023-36978-5
|
2023
|
| 37035174
|
Integrative analysis of transcriptomic landscape and urinary signature reveals prognostic biomarkers for clear cell renal cell carcinoma
|
Frontiers in Oncology
|
10.3389/fonc.2023.1102623
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
81802581
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82203134
|
|
|
|
| Submitter |
Wei
Zhang (zhweismmu@163.com)
|
| Organization |
Changhai Hospital, Second Military Medical University |
| Submission date |
2022-10-25 |
