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Accession PRJCA012795
Title The active extra X chromosome drives germ cell aplasia in klinefelter syndrome fetuses
Relevance Medical
Data types Transcriptome or Gene expression
Genome sequencing
Single cell sequencing
Organisms Homo sapiens
Description The primary pathological alteration in Klinefelter syndrome (KS) is germ cell loss. The alterations prior to loss and the molecular events in germ cells remain largely unknown. Through single-cell RNA sequencing of the gonads of KS and normal male fetuses, the phenotypes of KS fetal gonads and the molecular mechanisms were comprehensively investigated.
Sample scope Single cell
Release date 2024-06-08
Grants
Agency program Grant ID Grant title
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2019YFA0110001
National Natural Science Foundation of China (NSFC) National Science Funds for Distinguished Young Scholars 82125013
National Natural Science Foundation of China (NSFC) Young Scientists Fund 82101677
National Natural Science Foundation of China (NSFC) Young Scientists Fund 82101743
Peking University Third Hospital Clinical Cohort Construction Program BYSYZD201907
China Association for Science and Technology Young Elite Scientists Sponsorship Program YESS20200398
Submitter Liying Yan (yanliyingkind@aliyun.com)
Organization Peking University Third Hospital
Submission date 2022-10-27

Project Data

Resource name Description
BioSample (544)  show -