| 项目编号 |
PRJCA012926 |
| 项目标题 |
Proteogenomic Characterization Identifies Biological Insights and Subtype-Specific Therapeutic Strategies of Small Cell Lung Cancer. |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Genome sequencing
genomic, transcriptomic and proteomic sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Small cell lung cancer (SCLC) is a highly aggressive cancer with few therapeutic options. To delineate insights into SCLC biology and therapeutics, we performed comprehensive genomic, transcriptomic and proteomic characterization of SCLC using 112 tumors and paired normal adjacent tissues (NATs). |
| 样品范围 |
Multiisolate |
| 发布日期 |
2023-09-06 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
|
Cell
|
10.1016/j.cell.2023.12.004
|
2024
|
|
|
TRIM21-mediated ubiquitination of PARP1 suppresses small cell lung cancer progression through the PI3K/AKT/STAT5A axis
|
Research Square
|
10.21203/rs.3.rs-5464073/v1
|
2024
|
|
|
ARID1A governs genomic stability and proliferation in SCLC via c-MYC/PARP1 suppression driving vulnerability to BET inhibitors
|
Research
|
10.34133/research.0908
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
82125001
|
|
|
|
| 提交者 |
Peng
Zhang (zhangpeng1121@tongji.edu.cn)
|
| 提交单位 |
Shanghai Pulmonary Hospital Tongji University |
| 提交日期 |
2022-11-01 |
